美国印第安纳大学的Taylor等在研究用携带干扰素共有区（C-IFN）基因的腺病毒治疗小鼠乳腺癌时,意外地发现,仅接受腺病毒载体的对照小鼠的治愈率为80％。他们认为,该病毒能选择性杀伤肿瘤细胞,而不损伤健康细胞。 这种治疗的机理似为病毒溶瘤作用。由于仅注射腺病毒的小鼠的肿瘤p53表达量明显下降,而p53与侵袭性人类乳腺癌高度相关,因此,上述溶瘤作用可能起一定作用。 When Taylor et al. of Indiana University studied the treatment of breast cancer in mice with an adenovirus carrying the interferon consensus region (C-IFN) gene, it was unexpectedly found that the cure rate of control mice receiving only adenoviral vector was 80%. They believe that the virus can selectively kill tumor cells without damaging healthy cells. The mechanism of this treatment appears to be viral oncolysis. Since the expression of p53 in tumors of mice injected with adenovirus was significantly decreased, and p53 was highly correlated with invasive human breast cancer, the above oncolytic effects may play a role.