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目的探讨奥沙利铂神经毒性的预防措施。方法入选患者采用FOLFOX化疗方案,随机分为A、B两组。A组为观察组,卡马西平+硫酸镁+钙剂+化疗,在化疗前应用卡马西平100 mg,3次/d口服,连用5 d,硫酸镁1 g化疗前静脉推注,化疗后葡萄糖酸钙1 g静脉推注。B组为对照组,单纯化疗。结果随机对照研究,A组神经毒性发现率为29.4%。B组为61.1%。其中Ⅲ度神经毒性分别为2.9%和5.6%。结论钠离子通道阻滞剂可预防奥沙利铂的急性神经毒性,值得临床进一步探索应用。
Objective To investigate the preventive measures of neurotoxicity of oxaliplatin. Methods Selected patients were treated with FOLFOX chemotherapy and were randomly divided into A and B groups. Group A was treated with carbamazepine + magnesium sulfate + calcium + chemotherapy. Before the chemotherapy, carbamazepine was given 100 mg orally 3 times a day for 5 days, and magnesium sulfate 1 g was injected intravenously before chemotherapy. After chemotherapy, Calcium gluconate 1 g intravenous injection. Group B as control group, chemotherapy alone. Results of a randomized controlled study, A group of neurotoxicity was found in 29.4%. Group B was 61.1%. Grade III neurotoxicity was 2.9% and 5.6% respectively. Conclusion Sodium channel blockers can prevent the acute neurotoxicity of oxaliplatin, which is worth further exploration and application in clinic.