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为寻找新型肝靶向抗癌前药,将具有肝靶向特征的天然分子甘草次酸的半合成衍生物与抗癌药环磷酰胺的活性代谢物氮芥磷酰二氯偶联制成11-脱氧甘草次酸类两个目标化合物和7个中间体。化合物的化学结构用常规光谱分析法进行鉴定,对合成工艺、理化性质和光谱特征进行系统描述。本研究对甘草次酸类新型肝靶向抗癌前药的药理活性筛选奠定基础。
In order to find a new liver-targeting anticancer prodrug, semisynthetic derivatives of natural molecular glycyrrhetinic acid with liver-targeting properties were coupled with nitrogen mustard phosphoryl dichloride, the active metabolite of the anticancer drug cyclophosphamide - Two target compounds of deoxyglycyrrhetinic acid and seven intermediates. The chemical structures of the compounds were identified by conventional spectroscopic methods and the synthesis process, physicochemical properties and spectral characteristics were systematically described. This study laid the foundation for the pharmacological activity screening of glycyrrhetinic acid new type of liver-targeting anticancer prodrugs.