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生技霉素对围产期雌性小鼠口服给药 ,剂量 2 0和 5 0 0 mg/ kg,另用 0 .5 % CMC溶液作阴性对照。自然分娩后将给药组小鼠产仔数、仔重及畸形等情况与对照组相比较 ;取一定数量各组 F1 代小鼠继续配对饲养 ,检测其存活、生长发育、生殖、运动、学习能力及其他异常症状 ,并进行病理组织学检查。试验证明 ,生技霉素对围产期雌性小鼠口服给药 2 0和 5 0 0 mg/ kg,各项功能和病理观察等指标均与阴性对照组无明显差异 ,生技霉素对小鼠无围产期毒性。
Biotestomycin was orally administered to perinatal female mice at doses of 20 and 500 mg / kg, with 0.5% CMC solution as the negative control. After delivery, the number of littermate, weight, and deformity of the mice in the given group were compared with those in the control group after natural childbirth. F1 mice in each group were kept for mating and tested for survival, growth, reproduction, exercise and learning Ability and other abnormal symptoms, and histopathological examination. Tests show that biotechmycin oral administration of perinatal female mice 20 and 500 mg / kg, various functions and pathological indicators were not significantly different from the negative control group, Rat no perinatal toxicity.