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目的了解石家庄市肺结核耐药情况,为制定适合本地情况的结核病控制策略提供科学依据。方法对全市2012-2013年所有涂片阳性肺结核患者的痰标本进行痰培养,对培养阳性的菌株进行菌株鉴定和药敏试验。结果共收集861份痰涂片阳性的痰标本,培养阳性795份(92.33%),进行药敏试验中发现结核分枝杆菌耐药183份,总体耐药率为24.27%,初、复治肺结核患者耐药分别为100份和83份,耐药率分别为16.64%和54.25%。发现耐多药肺结核和广泛耐多药肺结核患者分别为62例和9例,耐药率分别为8.22%和1.19%;年龄组初复治患者耐药经统计学分析,差异有统计学意义(χ2=11.184,P<0.05)。结论规范患者服药管理、提高服药完成治疗率、减少复发是做好耐药肺结核病防治工作的前提条件。
Objective To understand the drug resistance of tuberculosis in Shijiazhuang and to provide a scientific basis for the development of tuberculosis control strategies suitable for local conditions. Methods Sputum culture was performed on sputum samples of all smear-positive pulmonary tuberculosis patients from 2012 to 2013 in the city, and strain identification and drug susceptibility test were carried out on the culture-positive strains. Results A total of 861 sputum smear-positive sputum samples were collected and positive for 795 (92.33%) were collected. Drug susceptibility tests showed that M. tuberculosis resistance was 183 and the overall drug resistance rate was 24.27%. Primary and retreatment tuberculosis Resistant patients were 100 and 83, respectively, the resistance rates were 16.64% and 54.25%. MDR-TB and MDR-TB were found to be 62 and 9, respectively, with rates of resistance of 8.22% and 1.19%, respectively. Statistical analysis was carried out on the drug resistance of patients in the early treatment group after the age group. The difference was statistically significant ( χ2 = 11.184, P <0.05). Conclusions It is a prerequisite for standardizing the administration of medication in patients, improving the rate of completion of treatment and reducing the recurrence rate of drug-resistant tuberculosis.