机械通气是挽救危重患者生命的重要措施。气管插管损害了患者呼吸系统的防御机制,导致呼吸机相关肺炎(ventilator-associated pneumonia,VAP)的发生,延长了机械通气时间和ICU停留时间。1 VAP发生机制气管插管阻碍了有效的咳嗽,并且口咽部分泌物和胃返流物沿气管插管积聚在气管插管气囊上方。目前广泛使用的高容低压(high-volume low-pressure,HV- Mechanical ventilation is an important measure to save the lives of critically ill patients. Endotracheal intubation damages the respiratory system defenses of patients, leading to the occurrence of ventilator-associated pneumonia (VAP) and prolonging the duration of mechanical ventilation and ICU stay. 1 VAP MECHANISM Tracheal intubation hinders effective cough, and oropharyngeal secretions and gastric reflux accumulate along the endotracheal tube over the endotracheal tube. Currently widely used high-voltage low-voltage (high-volume low-pressure, HV-