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我们观察了不同浓度的胰岛素对体外培养人血管平滑肌细胞增殖的影响，及其该过程中原癌基因ｃ－ｆｏｓ，ｃ－ｍｙｃ的表达。结果表明，胰岛素能促进血管平滑肌细胞（ＳＭＣ）增殖，即：ＳＭＣ数目的增多，ＳＭＣＤＮＡ的合成；胰岛素能促进原癌基因ｃ－ｆｏｓ和ｃ－ｍｙｃ的异常表达；且以上作用均存在着剂量－效应关系。这些结果提示，高胰岛素血症促进动脉粥样硬化（ＡＳ）发生、发展可能是通过促进某些原癌基因异常表达，进而促进ＳＭＣ增殖而实现的。这也许是某些基因治疗ＡＳ的基础。
We observed the effects of different concentrations of insulin on the proliferation of cultured human vascular smooth muscle cells in vitro and the expression of proto-oncogene c-fos and c-myc in this process. The results show that insulin can promote the proliferation of vascular smooth muscle cells (SMC), namely: SMC increased the number of SMCDNA synthesis; insulin can promote protooncogene c-fos and c-myc abnormal expression; and the above effects are there dose - Effect relationship. These results suggest that hyperinsulinemia promotes the development of atherosclerosis (AS), which may be caused by promoting the abnormal expression of some oncogenes and further promoting SMC proliferation. This may be the basis of some gene therapy AS.