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胃肠道恶性肿瘤是我国死亡率最高的恶性肿瘤之一,其发病率逐年上升,严重威胁着我国人民的生命健康。胃肠道恶性肿瘤患者的主要死亡原因是术后转移,目前临床上尚无可靠的方法对其早期诊断与有效防治。因此,探讨胃肠道肿瘤转移的分子机制,寻找与其转移相关的生物学标志,一直是临床与基础研究的重要课题之一。在研究癌细胞侵袭、转移过程中,许多学者注意到细胞外基质的重要性。细胞外基质(Extracellular matrix,ECM)是组成间质和上皮-血管中基质的不溶性结构成分,是细胞之间由多种蛋白和糖类组成的非细胞成分。它一方面起着支撑和连接细
Gastrointestinal cancer is one of the most serious malignant tumors in our country. The incidence of gastrointestinal cancer is increasing year by year, which seriously threatens the life and health of our people. The main cause of death in patients with gastrointestinal cancer is the postoperative metastasis, there is no reliable method for its early clinical diagnosis and effective prevention and treatment. Therefore, to explore the molecular mechanism of gastrointestinal tumor metastasis, to find the biological markers associated with its metastasis, has been an important issue in clinical and basic research. In the study of cancer cell invasion and metastasis, many scholars have noticed the importance of extracellular matrix. Extracellular matrix (ECM) is an insoluble structural component that makes up stroma and epithelial-vascular matrix. It is a non-cellular component composed of many proteins and carbohydrates. On the one hand it plays a supporting and connecting fine