目的 :观察原发性甲状腺非霍奇金淋巴瘤 (NHL)的病理形态特征 ,初步探讨其起源问题。方法 :通过HE及免疫组化染色观察 5例原发性甲状腺NHL ,并复习文献。结果 :5例原发性甲状腺NHL中 ,中心母细胞型 1例 ,中心细胞 中心母细胞混合型 2例 ,多形性免疫母细胞型 1例及粘膜相关淋巴组织 (MALT)淋巴瘤 1例。免疫组化结果显示瘤细胞均表达LCA、L2 6 ,其中 3例Kappa阳性 ,2例Lambda阳性。 结论 :原发性甲状腺NHL具有多种不同病理形态特征 ,原发性甲状腺NHL不一定都属于MALT淋巴瘤及由它发展而来的恶性度高的NHL。 Objective: To observe the pathological features of primary thyroid non-Hodgkin’s lymphoma (NHL) and to discuss its origin. Methods: Five cases of primary thyroid NHL were observed by HE and immunohistochemistry, and the literature was reviewed. Results: In 5 cases of primary thyroid NHL, there were 1 centroblastic cell type, 2 centroblastic mixed centroblasts, 1 pleomorphic immunoblastic cell type and 1 mucosal associated lymphoid tissue (MALT) lymphoma. The results of immunohistochemistry showed that the tumor cells expressed LCA, L2 6, of which 3 were Kappa positive and 2 lambda positive. Conclusion: The primary thyroid NHL has many different pathological features. The primary thyroid NHL may not all belong to the MALT lymphoma and the malignant NHL developed by it.