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在肿瘤治疗中,高温作为放射和化学治疗的一种辅助疗法的作用目前正为人们所逐渐认识.现已证明,局部或全身性加温对实验肿瘤或人体肿瘤的治疗都是有效的,并且随着加温至42℃以上,细胞的存活率下降,因此,通常用于肿瘤的高温为43℃。但是此温度对正常组织的安全性问题迄今仍未有足够的报道。因此,作者在本研究中以正常人体外周血单核细胞,其中包括T 细胞非T 细胞和巨噬细胞为材料,予以加温41～43℃,1～6小时。然后再以植物血凝素刺激,用DNA 复制作为高温损伤的指征,观察高温对正常细胞的损伤及其恢复能力。
In the treatment of tumors, the role of hyperthermia as an adjunctive therapy for radiation and chemotherapy is currently being recognized. It has been demonstrated that local or systemic warming is effective for the treatment of experimental tumors or human tumors, and As the temperature rises above 42°C, the viability of the cells decreases, and therefore, the high temperature usually used for tumors is 43°C. However, this temperature has not yet reported enough about the safety of normal tissues. Therefore, in this study, the authors used normal human peripheral blood mononuclear cells, including T-cell non-T cells and macrophages as materials, to be heated at 41-43°C for 1 to 6 hours. Then stimulated with phytohemagglutinin, using DNA replication as an indication of high-temperature damage, observed high temperature damage to normal cells and its ability to recover.