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患者,男,67岁,腹泻纳差腹胀1天半余,稀水样便,每日6次,无发热、无恶心呕吐。查大便常规wBC(+),诊断为肠炎。予以培氟沙星片口服,0.4g bid。服药后1小时出现恶心、呕吐,吐出物为胃内容物,呕吐后腹胀减轻,腹泻次数减少,服药1天后不再愎泻和腹胀,食欲渐次恢复正常。 讨论 对药物不良反应进行监测和调查研究是临床药理学研究的一项内容。培氟沙星片为第三代含氟喹喏酮类衍生物,其抗菌谱广,高效,可口服,很少有抗药菌株,又有致恶心、呕吐之作用。本病例患者未服用解热镇痛药和维生素类易引起胃肠道不适的药物,可排除药物间相互作用、食物中毒或变态反应等方面的因素。服药后的恶心、呕吐属于培
Patients, male, 67 years old, diarrhea, anorexia abdominal distension more than a day more than a half, watery stools, 6 times a day, no fever, no nausea and vomiting. Check stool routine wBC (+), diagnosed as enteritis. Pefloxacin tablets were given orally, 0.4g bid. 1 hour after taking nausea and vomiting, vomiting, stomach contents, vomiting, reduce bloating, reduce the number of diarrhea, medication after 1 day no longer diarrhea and bloating, appetite gradually returned to normal. Discussion Monitoring and investigating adverse drug reactions are part of clinical pharmacology. Pefloxacin tablets for the third generation of fluoroquinolone derivatives, its broad antibacterial spectrum, efficient, orally available, very few drug-resistant strains, but also caused nausea and vomiting. Patients in this case did not take antipyretics and vitamins easily cause gastrointestinal discomfort drugs, can rule out the drug interactions, food poisoning or allergic reactions and other factors. After taking the nausea, vomiting belongs to the training