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目的 :进一步探讨鼓室内注射庆大霉素治疗经保守治疗无效的梅尼埃病的疗效。方法 :选取 12例此种患者于鼓室内注射庆大霉素 (每 2～ 3d1次 ,连续 2～ 5次 ) ,密切观察临床症状、听力和眼震电图的变化。结果 :经随访 2～ 9年 ,并根据 1996年制定的梅尼埃病眩晕疗效评定标准 ,A级 (眩晕完全控制 ) 10例 ,B级 (眩晕基本控制 ) 2例。 4例耳鸣消失 ,3例减轻。主要并发症有听力下降和振动幻视。结论 :本治疗方法简单 ,安全有效 ,其疗效类似前庭神经切除术 ,可作为对经保守治疗和外科手术治疗无效的本病患者的首选治疗。
OBJECTIVE: To further investigate the curative effect of intravenous injection of gentamycin on Meniere’s disease with conservative treatment. Methods: Twelve patients with gentamicin (2 ~ 3d1times, 2 ~ 5 times consecutively) were injected into the tympanic cavity to observe the changes of clinical symptoms, hearing and electronystagmography. Results: The patients were followed up for 2 to 9 years. According to the criteria of Meniere’s disease vertigo curative effect established in 1996, there were 10 cases of grade A (complete dizziness control) and 2 cases of class B (basic dizziness control). 4 cases of tinnitus disappeared, 3 cases reduced. The main complications are hearing loss and vibration visual hallucination. Conclusion: The treatment is simple, safe and effective. Its curative effect is similar to that of vestibular neurectomy. It can be used as the first choice of treatment of patients with this disease who have not been treated conservatively or surgically.