本文旨在评价重组白细胞介素-1(IL-1)对脓毒性休克时心血管(CV)功能变化的作用。作者给10头犬输注含IL-1(1mg/kg)的林格液250 ml,15分钟输完。其中4只为对照,接受热处理过的无活性IL-1,6只接受活化IL-1,于输液后0、0.5、2、4、24、48、72、144和720 h测定血流动力学和放射性核素的左心室射血分数(LVEFs)。2小时时,与基值相比,对照组的肺 This article aims to evaluate the effect of recombinant interleukin-1 (IL-1) on changes in cardiovascular function during septic shock. The authors fed 250 ml of Ringer’s solution containing IL-1 (1 mg / kg) to dogs in 15 dogs. Four of them were controls, and inactive heat-treated IL-1 and 6 received activated IL-1 only. The hemodynamics were measured at 0, 0.5, 2, 4, 24, 48, 72, 144 and 720 h after infusion And radionuclide left ventricular ejection fraction (LVEFs). At 2 hours, the lungs of the control group were compared with the baseline values