对甲苯丙醚是农药、医药等合成的有机中间体。以往用 Williamson 法,即酚钠与卤代烷或草酸酯反应制备,但产率低,条件苛刻,操作繁琐。随着相转移催化技术在有机合成中的应用,Rowe 和王梦如报道了以溴化或氯化四丁基铵为相转移催化剂,用对甲苯酚和溴代正丙烷反应来制备。但这类季 Para-toluene propyl ether is a synthetic organic pesticide, pharmaceutical intermediates. In the past, the Williamson method was used to prepare sodium phenolate with alkyl halide or oxalate. However, the yield was low, the conditions were harsh, and the operation was cumbersome. With the application of phase transfer catalysis in organic synthesis, Rowe and Wang Mengru reported the use of bromination or tetrabutylammonium chloride as a phase transfer catalyst and p-cresol and brominated n-propane to prepare. But this season