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目的:总结并分析随年龄增长人体骨代谢的特征,探讨随年龄增长骨骼的变化,重点探讨老年人,尤其闭经后妇女骨代谢的特征,为防治骨质疏松症提供科学依据。资料来源:应用计算机检索Medline1993-01/2003-12年龄增长与骨代谢文章。检索词为“Thebonemetabolism,Theagegrowth,”并限定文章语种为English。同时从图书馆人工检索1993-01/2003-12的日文资料中有关年龄增长与骨代谢相关的文章。资料选择:对资料进行初审,纳入标准:①关于随年龄增长骨骼的生理性变化特征、机制、影响因素。②对临床病例回顾性研究分析;排除重复性研究内容。资料提练:符合上述要求的文章21篇,排除14篇重复性研究。7篇符合纳入标准:其中3篇为研究性论著,2篇为诊断标准,2篇为教科书。资料综合:随年龄增长骨代谢变化很大,在生长期骨骼逐渐成熟,骨骼钙量逐渐增加。一般到20岁以后骨代谢处于动态平衡,40岁以后骨代谢呈负增长,骨骼钙量减少。骨代谢变化是随年龄增长最剧烈、变化量最大的一个参数。老年人,尤其是妇女闭经后骨质疏松发生率增长很快,除因老年人退行性变外,还与内分泌紊乱等多种因素相关,通过研究为防治骨质疏松症提供科学依据。结论:在了解年龄增长与骨代谢关系的基础上,认识到防治骨质疏是可能的,主要是建立健康的生活方式,注意营养全面,摄入足量的含钙高的食物。
OBJECTIVE: To summarize and analyze the characteristics of human bone metabolism with age, explore the changes of bone with age, and focus on the characteristics of bone metabolism in the elderly, especially in postmenopausal women, so as to provide a scientific basis for the prevention and treatment of osteoporosis. Source: Applied Computer Retrieval Medline1993-01 / 2003-12 Age Growth and Bone Metabolism Articles. The search term is “Thebonemetabolism, Theagegrowth,” and the article language is limited to English. At the same time, the articles about aging growth and bone metabolism in Japanese data from January 1993 to December 2003 were retrieved manually from the library. Data selection: preliminary review of the data, including the criteria: ① on physiological aging with age changes in the characteristics of the mechanism and influencing factors. Retrospective analysis of clinical cases; exclude repetitive research content. Data Exercises: 21 articles meeting the above requirements, excluding 14 repetitive studies. 7 articles met the inclusion criteria: 3 of them were research articles, 2 were diagnostic criteria and 2 were textbooks. DATA SYNTHESIS: Bone metabolism changes greatly with age. During the growth phase, the bones gradually mature and the skeletal calcium content gradually increases. Generally 20 years of age after bone metabolism in a dynamic equilibrium, bone metabolism after the age of 40 showed a negative increase in bone calcium decreased. Bone metabolism changes with age is the most dramatic, the largest change in a parameter. The incidence of osteoporosis in the elderly, especially in women after menopause, has rapidly increased. Apart from the degenerative changes in the elderly, it is also associated with various factors such as endocrine disorders. It provides a scientific basis for the prevention and treatment of osteoporosis. Conclusion: On the basis of understanding the relationship between age and bone metabolism, we realized that it is possible to prevent and cure osteoporosis. The main purpose is to establish a healthy lifestyle, pay attention to nutrition and eat enough calcium-rich foods.