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目的研究丙戌酸钠治疗儿童热性惊厥的疗效。方法将86例热性惊厥患儿,按随机数字表法分为两组各43例。其中43例患儿给予地西泮、物理降温等常规治疗作为对照组,另43例患儿在给予丙戊酸钠治疗及物理降温等常规治疗作为观察组。结果对照组、观察组总有效率分别为81.40%、95.35%,观察组明显较高(P<0.05)。观察组患儿止惊时间、退热时间以及住院时间均明显短于对照组患儿(P<0.05)。观察组、对照组不良反应发生率分别为9.30%、6.98%,对比无差异(P>0.05);观察组复发率仅为4.65%低于对照组的16.28%(P<0.05)。结论丙戊酸钠在治疗儿童热性惊厥中具有良好效果,明显改善患儿症状,促进恢复,复发率低,安全性高。
Objective To study the efficacy of sodium propionate in the treatment of children with febrile seizures. Methods 86 cases of children with febrile seizures were divided into two groups according to random number table method, 43 cases each. 43 cases of children given diazepam, physical cooling and other conventional treatment as a control group, the other 43 cases of children given sodium valproate treatment and physical cooling and other conventional treatment as the observation group. Results The total effective rates of the control group and the observation group were 81.40% and 95.35% respectively, and the observation group was significantly higher (P <0.05). The observation group children only shock time, fever and hospital stay were significantly shorter than the control group (P <0.05). The incidences of adverse reactions in the observation group and control group were 9.30% and 6.98% respectively, with no significant difference between the two groups (P> 0.05). The recurrence rate in the observation group was only 4.65% lower than that in the control group (16.28%, P <0.05). Conclusion Sodium valproate has a good effect in the treatment of children with febrile seizures, significantly improves children’s symptoms, promotes recovery, low recurrence rate and high safety.