Acta Pharmacologica Sinica (APS) celebrates the 80-year anniversary of the establishment of SIMM by publishing this special issue to commemorate this event.APS,the official joual of the Chinese Pharmacological Society,has been published in association with SIMM since its Iaunch in 1980.The founding editor-in-chief,Prof Guang-sheng DING,and many prominent SIMM scientists have served on the APS editorial board in the past.With consistent support from SIMM,APS has grown to be Chinas leading inteational joual in the fields of pharmacology and pharmacy,publishing high quality papers from all over the world.To commemorate the 80th anniversary of SIMM,APS has organized this special issue including perspective,review and original articles contributed by principle investigators from SIMM in various disciplines[1-12].These articles highlight some of the research achievements accomplished at SIMM and provide an insight into the progress of drug research in China.