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目的：了解ＥＢ病毒ＩｇＡ／ＶＣＡ和ＩｇＡ／ＥＡ检测在鼻咽癌（ＮＰＣ）诊断中的价值。方法：ＩｇＡ／ＶＣＡ和ＩｇＡ／ＥＡ测定用间接免疫酶法，ＮＰＣ经活体组织检查确诊。结果：从１４８０例受检者中发现ＮＰＣ患者１２３例。ＮＰＣ患者的ＩｇＡ／ＶＣＡ阳性率为１００％，非ＮＰＣ者为２３．２１％，两者的几何平均滴度（ＧＭＴ）分别为１∶３９８．７和１∶１８．６，统计学差异非常显著（Ｐ＜０．００１）。ＮＰＣ患者的ＩｇＡ／ＥＡ阳性率为８１．３％，非ＮＰＣ者为０．８１％，两者的ＧＭＴ分别为１∶３３．６和１∶１２．１，统计学差异也非常显著（Ｐ＜０．００１）。９９．１％ＮＰＣ患者的ＩｇＡ／ＶＣＡ滴度在１∶４０以上，相反，７９．４％非ＮＰＣ者的ＩｇＡ／ＶＣＡ滴度在１∶２０以下。ＮＰＣ和非ＮＰＣ者的ＩｇＡ／ＥＡ、ＩｇＡ／ＶＣＡ的滴度分布构成Ｐ值分别为＜０．００１和０．０５，差异相似。结论：ＥＢ病毒ＩｇＡ／ＶＣＡ和ＩｇＡ／ＥＡ检测对ＮＰＣ的辅助诊断具有重要价值
Objective: To investigate the value of Epstein-Barr virus IgA / VCA and IgA / EA in the diagnosis of nasopharyngeal carcinoma (NPC). Methods: IgA / VCA and IgA / EA were determined by indirect immunoenzymatic method and NPC by biopsy. Results: 123 cases of NPC were found in 1480 subjects. The IgA / VCA positive rate was 100% in NPC patients and 23.21% in non-NPC patients. The geometric mean titers (GMTs) of NPC patients were 1:398.7 and 1:18.6, respectively. The statistical difference was significant (P <0.001). The positive rate of IgA / EA in NPC patients was 81.3% and that in non-NPC patients was 0.81%. The GMT of NPC patients was 1:33.6 and 1:12.1, respectively. The statistical difference was also significant (P < 0.001). IgA / VCA titers of 99.1% of NPC patients were above 1:40, whereas 79.4% of non-NPC patients had IgA / VCA titers below 1:20. The titers of IgA / EA and IgA / VCA in NPC and non-NPC were P <0.001 and 0.05, respectively, with similar differences. Conclusion: The detection of Epstein-Barr virus IgA / VCA and IgA / EA is of great value in the auxiliary diagnosis of NPC