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目的探讨短暂性脑缺血发作(TIA)患者血清神经元特异性烯醇化酶(NSE)动态变化及其临床意义。方法选取在医院接受治疗的短暂性脑缺血发作患者50例,为观察组。选取同期健康体检患者50例为对照组,检测短暂性脑缺血发作患者在入院24 h内和入院5 d时血清NSE水平。根据神经功能缺失症状持续时间将50例观察组分为短症状组(小于等于6 h)和长症状组(6 h以上),观察不同神经功能缺失症状持续时间与NSE关系。结果观察组在入院24 h时,NSE为(24.65±3.23)μg/L,入院5 d NSE为(19.42±2.78)μg/L;对照组在入院24 h时,NSE为(14.65±2.33)μg/L,入院5 d NSE为(14.65±2.33)μg/L。观察组在入院24 h时,NSE水平明显高于对照组,入院5 d后,NSE水平与入院时比较有明显下降,但仍高于对照组,差异有统计学意义(P<0.05)。长症状组在入院24 h时,NSE为(29.63±2.27)μg/L,入院5 d NSE为(24.43±2.43)μg/L;短症状组在入院24 h时,NSE为(21.64±2.24)μg/L,入院5 d NSE为(14.45±2.64)μg/L。两组患者在入院5 d NSE水平均有明显下降,但是长症状组在入院25 h和入院5 d时NSE水平均明显高于短症状组,差异有统计学意义(P<0.05)。结论短暂性脑缺血发作患者血清NSE明显升高,且随神经功能缺损时间呈正相关,对疾病的诊断和预后具有提示作用。
Objective To investigate the dynamic changes of serum neuron specific enolase (NSE) in patients with transient ischemic attack (TIA) and its clinical significance. Methods Fifty patients with transient ischemic attack who were treated in the hospital were selected as the observation group. Fifty patients in the same period of healthy physical examination were selected as the control group to detect the level of serum NSE within 24 h after admission and 5 d after admission in patients with transient ischemic attack. According to the duration of neurological deficit symptoms, 50 cases were divided into short symptom group (less than or equal to 6 hours) and long symptom group (more than 6 hours) to observe the relationship between the duration of neurological deficit symptoms and NSE. Results In the observation group, the NSE was (24.65 ± 3.23) μg / L at 24 h admission and (19.42 ± 2.78) μg / L at 5 d after admission. The NSE was 14.65 ± 2.33 μg / L, NSE on admission 5 d was (14.65 ± 2.33) μg / L. The level of NSE in observation group was significantly higher than that in control group 24 h after admission. After 5 d admission, NSE level decreased significantly compared with that at admission, but still higher than that in control group (P <0.05). NSE was (29.63 ± 2.27) μg / L at 24 h after admission and (24.43 ± 2.43) μg / L at 5 d after admission in the long symptom group. NSE was (21.64 ± 2.24) μg / L, NSE on the 5th day after admission was (14.45 ± 2.64) μg / L. NSE levels in both groups decreased significantly on the 5th day after admission. However, the NSE levels of the long group were significantly higher than those of the short-term group at 25 h admission and 5 d admission (P <0.05). Conclusion The serum NSE in patients with transient ischemic attack is significantly increased, and positively correlated with the time of neurological deficit, suggesting that the serum NSE may be helpful to the diagnosis and prognosis of the disease.