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目的比较血清半胱氨酸蛋白酶抑制剂C(CystatinC)、肌酐(Scr)、肌酐清除率(Ccr)在慢性肾病(CKD)患者各期与估算的肾小球滤过率(eGFR)的符合率。方法血清CystatinC采用免疫透射比浊法测定,Scr和尿肌酐采用酶法测定,基于Scr估算的eGFR采用MDRD方程进行计算,CKD患者根据1999年美国肾病基金会(NKF)公布的K/DOQI指南按eGFR分为5期。结果198例CKD患者各期CystatinC,Scr随eGFR的降低而逐渐升高,Ccr随eGFR的降低而逐渐降低,三者在各期间水平的差异均有统计学意义(P<0.05)。结论检测CystatinC和Ccr可以早期发现GFR的下降。
Objective To compare the coincidence rates of serum cystatin C, creatinine (Scr) and creatinine clearance (Ccr) with estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease (CKD) . Methods Serum Cystatin C was determined by immunoturbidimetry, Scr and urinary creatinine were determined by enzymatic method. The eGFR based on Scr was calculated by MDRD equation. According to the K / DOQI guidelines published by the National Kidney Foundation (NKF) in 1999 eGFR is divided into 5 phases. Results Cystatin C and Scr in all the 198 CKD patients gradually increased with the decrease of eGFR. Ccr decreased gradually with the decrease of eGFR. The differences among the three groups were statistically significant (P <0.05). Conclusion Detecting Cystatin C and Ccr can detect the decline of GFR early.