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血管紧张素Ⅱ-1型受体(AT1R)基因是肾素-血管紧张素系统(RAS)中介导血管收缩、水盐代谢及血管平滑肌增生和功能调节等生理学效应的重要组分,该基因位于3’端的A1166C 多态性被认为与原发性高血压(EH)相关,但也有研究得到了不一致的结论,认为该多态性对于 EH 的发生无重要作用。本研究对136名健康者(对照组)和141例EH 患者(EH 组)进行 AT1R 基因型检测,同时进行问卷调查、医学体检和血液生化项目检测,旨在探讨浙江省居民AT1R 基因 A1166C 多态性与 EH 的关系,并从分子水平探讨
The angiotensin Ⅱ type 1 receptor (AT1R) gene is an important component of physiological effects in the renin-angiotensin system (RAS) that mediates vasoconstriction, water and salt metabolism and vascular smooth muscle proliferation and function regulation. The gene The A1166C polymorphism at the 3’end is considered to be associated with essential hypertension (EH), but other studies have found inconsistent conclusions that the polymorphism is not important for the development of EH. In this study, AT1R genotypes were detected in 136 healthy controls (control group) and 141 EH patients (EH group). At the same time, questionnaires, medical examinations and blood biochemical tests were performed to investigate the polymorphism of AT1R gene A1166C The relationship between sex and EH, and from the molecular level to explore