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米索前列醇是一种合成的前列腺素类似物,自1988年在拉丁美洲一些国家用于非法坠胎以来,到1998年由于孕期使用米索前列醇使胎儿致畸的数目已增加到53例,文献报道较多的有5种畸形,包括马蹄内翻足、脑积水、末端肢体横断畸形、关节弯曲以及肢体收缩环。到目前为止,文献报道大约15种先天畸形可能与应用米索前列醇有关。
Misoprostol is a synthetic prostaglandin analogue that has been used in illegal pregnancies in some countries in Latin America since 1988 and has increased the number of teratogenic aspects of the fetus due to misoprostol during pregnancy to 53 in 1998 There are 5 deformities reported in the literature, including clubfoot, hydrocephalus, transected limb deformity, joint flexion and limb constriction. So far, about 15 cases of congenital malformations reported in the literature may be related to the application of misoprostol.