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目的探讨亚临床甲状腺功能减退(SCH)合并妊娠期糖尿病(GDM)孕妇血清NF-κB、IL-6、IL-8的表达及相关关系。方法选取2013~2014年在唐山市妇幼保健院妇产科检查的SCH合并GDM孕妇44例为观察组,同期健康体检孕妇50例为对照组。采用贝克曼DXI800化学发光分析仪检测促甲状腺素(TSH),ELISA法检测血清白细胞介素6(IL-6)、IL-8、细胞培养液核因子κB(NF-κB),对结果进行分析比较。结果 SCH合并GDM孕妇血清IL-6、IL-8及细胞培养液NF-κB水平高于对照组,差异有统计学意义(P<0.05);NF-κB、IL-6、IL-8与TSH呈正相关(r=0.321~0.454,P<0.05)。结论 NF-κB、IL-6、IL-8可能参与SCH合并GDM的病理生理过程,其可作为SCH合并GDM早期诊断、治疗和预后判断的重要指标。
Objective To investigate the expressions of serum NF-κB, IL-6 and IL-8 in subclinical hypothyroidism (SCH) and gestational diabetes mellitus (GDM). Methods From 2013 to 2014, 44 males with GDM combined with SCH in gynecology and obstetrics examination in Tangshan Maternal and Child Health Hospital were selected as the observation group, and 50 healthy pregnant women in the same period were selected as the control group. Serum levels of IL-6, IL-8 and NF-κB were detected by Beckman DXI800 chemiluminescence analyzer and the results were analyzed by ELISA Compare Results The levels of serum IL-6, IL-8 and cell culture medium NF-κB in SCH group with GDM were significantly higher than those in control group (P <0.05). NF-κB, IL-6 and IL- (R = 0.321 ~ 0.454, P <0.05). Conclusions NF-κB, IL-6 and IL-8 may be involved in the pathophysiological process of SCH with GDM combined with GDM, which may be used as an important index for the early diagnosis, treatment and prognosis of GDM with SCH.