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头臀长为10～15mm(E13～15天)SD胚鼠腹侧中脑(富多巴胺神经元)移植至23只帕金森病鼠纹状体中。14只行为改善鼠在经过不同成活期(1～2、3～4、8～12月)后处死,进行了酪氨酸羟化酶(TH)免疫组化研究。在不同成活期移植区的TH阳性细胞由成簇密集至成串分散;由散乱分布至沿着移植区周缘分布;移植区从有明显分界至渐不明显而呈现与受体整合。表明移植组织在受体脑内能长期存活并与受体脑整合;去神经的纹状
10 to 15 mm of head hip length (E13 to 15 days) SD embryos ventral mesencephalon (dopamine-rich neurons) were transplanted into the striatum of 23 Parkinson’s disease rats. Fourteen behavior-improving rats were sacrificed after different stages of survival (1~2, 3~4, and 8~12 months) and tyrosine hydroxylase (TH) immunohistochemistry was performed. TH positive cells in the transplanted area at different stages of survival were clustered to clustered; scattered and distributed along the periphery of the transplanted area; the transplanted area showed integration with the receptors from a clear demarcation to becoming insignificant. Shows that transplanted tissue can survive long-term in the recipient brain and integrate with the recipient brain; denervation striate