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目的分析同型半胱氨酸(Hcy)水平与帕金森病(PD)伴发抑郁症状之间的关系。方法除搜集一般资料外,对两组对象均行UPDRSⅢ运动状态评分、H-Y分期评定、HAMD抑郁量表、Mo CA认知功能及血浆Hcy、叶酸、维生素B12检测。结果 1 PD组的Hcy值及HAMD评分显著高于健康对照组,而叶酸值及Mo CA评分显著低于健康对照组,均具有统计学意义(P<0.05);275例PD患者,伴发抑郁症状42例,发生率56.0%(42/75),其中轻中度抑郁为76.19%(32/42);3与PD无抑郁症状组比较,PD伴发抑郁症状组存在运动症状重、病情分期重、认知功能评分低、血浆Hcy高、叶酸水平低,具有显著统计学意义;4Hcy与HAMD评分呈正相关,相关系数0.556(P=0.00);叶酸与HAMD评分呈负相关,相关系数-0.482(P=0.00);Moca评分与HAMD评分呈负相关,相关系数-0.597(P=0.00)。结论 PD伴发抑郁的危险因素包括运动症状重、病情分级重及认知评分低,血浆Hcy高,并且血浆Hcy水平越高,认知损害越重,抑郁程度越重。
Objective To analyze the relationship between homocysteine (Hcy) level and depressive symptoms associated with Parkinson’s disease (PD). Methods In addition to collecting general information, UPDRS Ⅲ motor status score, H-Y staging, HAMD depression scale, MoCA cognitive function and plasma Hcy, folic acid and vitamin B12 were detected in both groups. Results The Hcy and HAMD scores of 1 PD group were significantly higher than those of healthy control group, but the values of folic acid and Mo CA were significantly lower than those of healthy control group (P <0.05); 275 patients with PD accompanied with depression The symptoms were 42 cases, the incidence rate was 56.0% (42/75), mild to moderate depression was 76.19% (32/42) .3 Compared with PD without depressive symptoms group, there were motor symptoms, (P = 0.006). There was a positive correlation between 4Hcy and HAMD score, the correlation coefficient was 0.556 (P = 0.00), the correlation between folic acid and HAMD score was negative, and the correlation coefficient was -0.482 (P = 0.00). The Moca score was negatively correlated with HAMD score, with a correlation coefficient of -0.597 (P = 0.00). Conclusions The risk factors of PD with depression include motor symptoms, grading of disease, low cognitive score, high plasma Hcy, higher plasma Hcy level, more severe cognitive impairment and more depression.