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莫斯科结核病研究所为了找出一种便于监督化疗的方法,研究了10%异烟肼肌注治疗283例肺结核的效果。其中包括202例住院的严重破坏型肺结核(Ⅰ组)以及完成住院治疗进入门诊治疗的81例病人(Ⅱ组)。两组均于综合化疗中应用10%异烟肼肌注。Ⅰ组病人年龄20～50岁,男143、女59例。其中浸润型131例,播散型38例,纤维空洞型37例,其他类型6例。排菌190例,绝大部分为大量排菌者。其中重症167例,空洞不只1个者153例。以前未进行抗结核治疗或已进行但不足1个月者158例;病变进展缓慢,以往阶段治疗无效者44例,其中13例>1年。在最初3～4个月强化治疗阶段采用10%异烟肼肌注
In order to find a way to monitor chemotherapy, the Moscow Tuberculosis Institute studied the effect of 10% isoniazid intramuscular injection on 283 cases of tuberculosis. These included 202 hospitalized patients with severe TB (group Ⅰ) and 81 patients (group Ⅱ) who completed hospitalization for outpatient treatment. Both groups were given intramuscular 10% isoniazid in combination chemotherapy. Group Ⅰ patients aged 20 to 50 years, male 143, female 59 cases. Among them, 131 cases were infiltration, 38 cases were disseminated, 37 cases were fibrous cavities and 6 cases were other types. Discharge 190 cases, most of the large number of bacteria row. Among them, 167 cases were severe and there were 153 cases with more than 1 cavity. 158 patients who had not been previously treated for anti-TB or had undergone but less than 1 month had slow progression of disease, 44 patients were ineffective in the previous stage, of which 13 were> 1 year. In the first 3 to 4 months of intensive treatment with 10% isoniazid intramuscular injection