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用一组抗淋巴细胞的单克隆抗体和免疫组化方法,对30例晚期宫颈癌浸润的淋巴细胞进行原位分析,发现癌组织中浸润的细胞以T细胞为主,且主要分布在间质,但很少活化。实质中浸润的细胞远较间质为少,且主要为T_8~-细胞,这与间质中T_4~+细胞相对较多完全不同,上述发现与文献中报道的肺癌、肠癌、胃癌等结果一致。另外,30例宫颈癌中,15例癌细胞为HLA-DR~+,15例为阴性。比较DR~+癌和DR~-癌中浸润的细胞,发现癌实质及间质中有更多的T_8~+细胞浸润,而二组中的T_4~+细胞及其它浸润细胞并无显著差异。这一发现与自身免疫时DR~+上皮细胞部位有更多的T_4~+细胞浸润的事实相反。
A group of anti-lymphocyte monoclonal antibodies and immunohistochemical methods, in situ analysis of 30 cases of advanced cervical cancer infiltrating lymphocytes found that infiltrating cells in cancer tissue to T cells, and mainly distributed in the stroma , But rarely activated. The infiltrating cells were much less than the interstitial cells, and mainly T_8 ~ - cells, which is quite different from the T_4 ~ + cells in the interstitium. The above findings are related to the results of lung cancer, intestinal cancer and gastric cancer reported in the literature Consistent. In addition, 30 cases of cervical cancer, 15 cases of cancer cells for HLA-DR ~ +, 15 cases were negative. Compared with the infiltrating cells in DR ~ + and DR ~ - cancers, there were more T8 + cells infiltrating into the parenchyma and interstitium, while there was no significant difference between T4 + cells and other infiltrating cells in the two groups. This finding is contrary to the fact that there is more T 4 + cell infiltration in the DR + epithelial cell site during autoimmunity.