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瘦素(leptin)与多囊卵巢综合征(PCOS)的关系及leptin在生殖中的作用引人注目。测定血清、卵泡液、脑脊液中leptin水平及全身各脏器leptin受体mRNA的表达提示。PCOS妇女leptin水平增高,肥胖PCOS者增加尤甚,体重指数(BMI)是最根本的决定因素。卵巢、子宫、脂肪组织、下丘脑等组织均有leptin受体,leptin不仅可以通过外周循环作用于下丘脑-垂体-卵巢轴,也可通过卵泡液直接作用于卵巢。leptin可影响PCOS妇女的体重、神经内分泌、卵巢功能和生育功能。而PCOS也可调节leptin的合成、分泌及其功能效应。
The relationship between leptin and polycystic ovary syndrome (PCOS) and the role of leptin in reproduction attract attention. The level of leptin in serum, follicular fluid and cerebrospinal fluid and the expression of leptin receptor mRNA in various organs of the body were detected. PCOS women leptin levels increased, especially in obese PCOS increased more than the body mass index (BMI) is the most fundamental determinants. Ovaries, uterus, adipose tissue, hypothalamus and other tissues have leptin receptor, leptin not only through the peripheral circulation in the hypothalamus - pituitary - ovarian axis, but also through the follicular fluid directly on the ovary. Leptin affects the body weight, neuroendocrine, ovarian and reproductive functions of women with PCOS. PCOS also regulates leptin synthesis, secretion and its functional effects.