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(1)分析我科1971年至1978年收治的8例甲状腺机能亢进并有黄疸患者的黄疸发生原因,其中3例与甲亢本身疾病有关,5例是甲状腺机能亢进合并病毒性肝炎,无1例药物所致的黄疸。(2)复习有关文献对甲状腺机能亢进发生黄疸的机制进行了探讨:甲状腺机能亢进可以促使病毒性肝炎病情加剧,并发危象和充血性心衰。甲状腺机能亢进患者可以发生黄疸,单纯性甲状腺机能亢进可以激发隐性肝病导至黄疸的发生。(3)甲状腺机能亢进可以加重肝炎,而抗甲状腺药物产生肝损害的病例少见,因此当其合并病毒性肝炎时,尤其在甲状腺机能亢进症状明显时,我们主张在密切观察下使用抗甲状腺药物治疗。对过敏体质者则慎用。
(1) analysis of our department from 1971 to 1978 admitted to 8 cases of hyperthyroidism and jaundice in patients with jaundice causes, of which 3 cases with hyperthyroidism disease itself, 5 cases of hyperthyroidism with viral hepatitis, no one case Drug-induced jaundice. (2) to review the literature on the pathogenesis of jaundice in hyperthyroidism were discussed: hyperthyroidism can promote the exacerbation of viral hepatitis, complicated by crisis and congestive heart failure. Hyperthyroidism can occur in patients with jaundice, simple hyperthyroidism can lead to latent liver disease leading to the occurrence of jaundice. (3) Hyperthyroidism can exacerbate hepatitis and anti-thyroid drugs produce rare liver damage. Therefore, when combined with viral hepatitis, especially when the symptoms of hyperthyroidism are obvious, we advocate the use of anti-thyroid drugs in close observation . For those with allergies are used with caution.