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妊娠相关性血浆蛋白 A(PAPP A)是一种锌结合金属蛋白酶 ,近年来发现在急性冠状动脉综合征患者血清中 ,其浓度明显升高 ,预示可以作为不稳定斑块的识别标志之一。本文就PAPP A的分子结构、生物学特点及在急性冠脉综合征中的临床意义作一简要综述。
Pregnancy-associated plasma protein A (PAPP A) is a zinc-binding metalloproteinase that has been found to be significantly elevated in the serum of patients with acute coronary syndromes in recent years, suggesting that it may serve as one of the hallmarks of unstable plaque. This article reviews the molecular structure, biological characteristics and clinical significance of PAPP A in acute coronary syndromes.