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目的:探讨中药制剂糖脂平颗粒(TZP)对实验性2型糖尿病(T2DM)大鼠血脂的影响。方法:采用高脂饲料加小剂量腹腔注射链脲佐菌素(STZ)造模,分别给糖脉康颗粒、糖脂平颗粒进行干预,测定干预后空腹血糖(FPG)、胆固醇(TG)、甘油三脂(TC)、高密度脂蛋白(HDL-C)、和低密度脂蛋白(LDL-C)水平。结果:糖脂平颗粒可降低T2DM大鼠FPG、TG、TC、LDL-C水平,增高HDL-C。结论:TZP可较明显降低血糖、血脂,对2型糖尿病有一定疗效。
Objective: To investigate the effect of Tangzhiping Granule (TZP) on blood lipid in experimental type 2 diabetes mellitus (T2DM) rats. Methods: High fat diet plus low dose of streptozotocin (STZ) intraperitoneal injection were given to the intervention of Tangmaikang granule and Tangzhiping granule respectively. The levels of fasting blood glucose (FPG), cholesterol (TG) TC, HDL-C, and LDL-C levels. Results: Tangzhi tablet can reduce the level of FPG, TG, TC and LDL-C in T2DM rats and increase HDL-C. Conclusion: TZP can significantly lower blood glucose, blood lipids, type 2 diabetes have a certain effect.