论文部分内容阅读
目的探讨选择性头部亚低温治疗对新生儿缺氧缺血性脑病(HIE)血清氧化应激因子及神经评分的影响。方法选取2014年8月-2016年10月西安高新医院收治的HIE患儿88例,采用随机数字法将其分为对照组和观察组,每组各44例。对照组患儿接受常规综合治疗干预,观察组在此基础上接受选择性头部亚低温治疗,连续治疗28 d。比较两组患儿的治疗总有效率及治疗后神经行为评分(NBNA),比较治疗前后血清超氧化物歧化酶(SOD)、血清丙二醛(MDA)、白细胞介素-18(IL-18)及半胱氨酸天冬氨酸蛋白水解酶3(Caspase-3)水平。结果观察组治疗总有效率(95.45%)明显高于对照组(79.54%)(χ2=5.09,P=0.02);治疗后,观察组血清SOD水平明显高于对照组(P<0.01),MDA、IL-18及Caspase-3水平明显低于对照组(P<0.01);出生后14 d、28 d,观察组NBNA评分均明显高于对照组(P<0.05)。结论选择性头部亚低温治疗HIE的临床疗效显著,能降低脑部缺血再灌注后的氧化应激损伤,有效保护脑部神经,提高患儿预后质量,值得临床推广。
Objective To investigate the effects of selective head mild hypothermia on serum oxidative stress factors and neural score in neonates with hypoxic-ischemic encephalopathy (HIE). Methods Eighty-eight HIE children admitted to Xi’an High-tech Hospital from August 2014 to October 2016 were randomly divided into control group and observation group, with 44 cases in each group. The control group of children received routine comprehensive treatment intervention, the observation group on the basis of selective head mild hypothermia treatment, continuous treatment 28 d. The total effective rate and neurological behavior score (NBNA) were compared between the two groups before and after treatment. The levels of serum superoxide dismutase (SOD), serum malondialdehyde (MDA), interleukin-18 ) And caspase-3 levels. Results After treatment, the total effective rate (95.45%) in the observation group was significantly higher than that in the control group (79.54%) (χ2 = 5.09, P = 0.02) , IL-18 and Caspase-3 levels in the observation group were significantly lower than those in the control group (P <0.01). On the 14th and 28th day after birth, the NBNA scores in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Selective head mild hypothermia in the treatment of HIE has significant clinical curative effect, which can reduce the oxidative stress injury after cerebral ischemia-reperfusion, effectively protect the brain nerve and improve the quality of prognosis of children, which deserves clinical promotion.