川崎病（KD)是一种病因不明的全身中小血管炎症综合征。目前公认的疗法为单次静脉注射丙种球蛋白(IVIG)联合阿司匹林口服，但仍有大于10%的患儿对初次IVIG治疗无应答。因此，尽早识别IVIG无反应KD，并给予积极治疗，对于改善其远期预后十分关键。本文综述了IVIG无反应KD的危险因素、和预测评分体系。“,”Kawasaki disease (KD) is a kind of unknown etiology of systemic small vascular inflammation syndrome. Now recognized therapy for single intravenous gamma globulin (IVIG) in combination with aspirin oral, but there are still more than 10%of children for initial IVIG treatment no answer. Therefore, early identification IVIG unresponsive to KD, and give positive treatment, to improve the long-term prognosis is critical. This paper summarizes the risk factors of IVIG unresponsive KD, and predictive scoring system.