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核黄素(riboflavin)是辅因子黄素腺嘌呤二核苷酸(flavin adenine dinucleotide,FAD)和黄素单核苷酸(flavin mononucleotide,FMN)的前体物。植物和许多微生物能自身合成,动物需从饮食中获取,因此核黄素生物合成途径相关酶可作为抗生素设计和开发的潜在靶标。文中对核黄素生物合成关键酶二氧四氢蝶啶合成酶(lumazine synthase,LS)和核黄素合成酶(riboflavin synthase,RS)抑制剂的高通量筛选法及研究现状进行综述,以期为新抗生素的开发提供有用的线索和策略。
Riboflavin is a precursor of the cofactor flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). Plants and many microbes can synthesize on their own and animals need to be taken from the diet so the enzymes involved in the riboflavin biosynthesis pathway can serve as potential targets for the design and development of antibiotics. In this paper, the high throughput screening methods and research status of riboflavin biosynthesis key enzymes such as lumazine synthase (LS) and riboflavin synthase (RS) inhibitors were reviewed. Provide useful clues and strategies for the development of new antibiotics.