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从生药角蒿(Incarvillea sinensis,全草)中分离出单萜烯生物碱衍生物Incarvillateine,对甲醛致痛具有较强的镇痛作用。此次对Incarvillateine的作用机制进行了研究。 在4周龄ddY系雄性小鼠的足跖部皮下注射1％甲醛20μl.记录投与0～10min(第一时相)及10～30min(第二时相)小鼠舔足行为时间(Licking time)。腹腔内注射给药。
Separation of monoterpene alkaloid derivatives Incarvillateine from Artemisia hornia (Incarvillea sinensis) has a strong analgesic effect on formaldehyde. The mechanism of action of Incarvillateine was studied this time. Four-week-old ddY male mice were injected subcutaneously with 1% formaldehyde (20 μl) in the ankle and foot. The mice were recorded for 0 to 10 minutes (first phase) and 10 to 30 minutes (second phase) for acolysis time (Licking time). ). Intraperitoneal injection.