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D-青霉胺(D-PA)由于剂量高、疗程长,故纯度控制甚为重要。其异构体L-青霉胺(L-PA)在蛋白质合成中与L-缬氨酸、L-异亮氨酸进行竞争,因而是毒副反应的主要来源,必须严加控制。文献报道的核磁共振法费时长,检测限度仅0.5%。作者使用特丁氧基-L-亮氨酸-N-羟基琥珀酰亚胺
D-Penicillamine (D-PA) Purity control is important due to the high doses and long duration of treatment. Its isomer L-penicillamine (L-PA) competes with L-valine and L-isoleucine in protein synthesis and is therefore the major source of toxic side effects and must be controlled. Time-consuming NMR method reported in the literature, the detection limit of only 0.5%. The authors used terbutyloxy-L-leucine-N-hydroxysuccinimide