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本文以正常人及阵发性睡眠性血红蛋白尿症(PNH)患者的红细胞为对象,观察阿魏酸钠对补体溶血的影响及其机理。结果说明阿魏酸钠可明显降低补体溶血,抑制补体3b(C_3b)与红细胞膜的结合;对补体激活及红细胞变形性无影响。
In this article, the effects of sodium ferulate on complement hemolysis and its mechanism were observed in normal humans and patients with paroxysmal nocturnal hemoglobinuria (PNH). The results showed that sodium ferulate can significantly reduce complement hemolysis and inhibit the binding of complement 3b (C_3b) to the erythrocyte membrane; it has no effect on complement activation and erythrocyte deformability.