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目的:探讨血清IL-8水平在慢性阻塞性肺疾病(COPD)中的作用及临床意义。方法:采用酶联免疫吸附法(ELISA)检测COPD患者急性期、稳定期及正常人的血清IL-8水平。结果:COPD患者急性期血清IL-8水平明显高于稳定期及正常对照组水平,差异有显著性(P<0.05,P<0.01)。COPD患者稳定期血清IL-8水平明显高于正常对照组水平,差异有显著性(P<0.01)。结论:血清IL-8间接反映COPD病情严重程度,可作为监测治疗的一个重要指标。
Objective: To investigate the role of serum IL-8 in chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods: Serum levels of IL-8 in acute, stable and normal COPD patients were detected by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of IL-8 in acute phase of COPD patients were significantly higher than those in stable and normal controls (P <0.05, P <0.01). The level of serum IL-8 in stable patients with COPD was significantly higher than that in normal controls (P <0.01). Conclusion: Serum IL-8 indirectly reflects the severity of COPD and can be used as an important indicator of monitoring and treatment.