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由于目前临床对药物的生物利用度越来越重视,常常将两种药液配合使用,这虽可增强药物的疗效,但也增加了许多配伍变化。尤其是葡萄糖注射液,中国药典二部规定其PH为3.2～5.5,其间氢离子浓度相差约200倍,变化范围较大。当难溶性弱酸盐与葡萄糖注射液配伍使用时,会析出难溶性弱酸而产生混浊、沉淀、结晶的可能性极大,从而影响药物的使用和疗效。同时,一些微小结晶还会堵塞毛细血管,容易引起局部刺激与静脉炎。
Due to the current clinical bioavailability of the drug more and more attention, often with the two kinds of liquid with the use, although this can enhance the efficacy of the drug, but also increased the compatibility of many changes. In particular, glucose injection, the Chinese Pharmacopoeia two provisions of its PH 3.2 ~ 5.5, during which a difference of about 200 times the hydrogen ion concentration, a wide range of changes. When the insoluble salts and glucose injections compatibility, it will precipitate insoluble acid and produce turbidity, precipitation, crystallization is extremely likely to affect the use of drugs and efficacy. At the same time, some small crystals will plug the capillaries, easily lead to local irritation and phlebitis.