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缺血性心脏病患者血小板功能活性增高,其血栓生成多于纤维蛋白的生成,因此肝素和间接抗凝剂这些药物治疗效果不满意。阿斯匹林是抗血小板凝集的最常用药物,可降低心肌梗死的复发频率和因心血管疾病导致的死亡。材料和方法:研究对象为进行性心绞痛患者27例(男22例,女5例),平均年龄61.7±4.8岁。静脉注射阿斯吡唑500～2000mg,1次/d,5～10日,后数日加服阿斯匹林0.5g/d,分别在治疗前、注射阿斯吡唑后1h、24h和服用阿斯匹林后第5日,对凝血情况进行研究,对5例患者的心电图进行重复检查。结果和讨论:血小板自发凝集(SAT)增强者18例(66.7%),平均增高达43.2%±4.68%。注射阿斯吡唑后,14例(77.8%)SAT降低,1h后为22.9%士
Platelet function in patients with ischemic heart disease increased, thrombosis more than the formation of fibrin, heparin and indirect anticoagulants these drugs are not satisfied with the treatment effect. Aspirin is the most commonly used anti-platelet aggregation drug that reduces the frequency of recurrent MI and death due to cardiovascular disease. MATERIALS AND METHODS: Twenty-seven patients (22 males and 5 females) with angina were studied. The mean age was 61.7 ± 4.8 years. Intravenous aspirazole 500 ~ 2000mg, 1 / d, 5 to 10 days after the first plus aspirin 0.5g / d, respectively, before treatment, after injection of aspirazole 1h, 24h and taking On the 5th day after aspirin, the coagulation situation was studied and the electrocardiogram of five patients was examined repeatedly. RESULTS AND DISCUSSION Eighteen patients (66.7%) with increased platelet spontaneous coagulation (SAT) achieved an average increase of 43.2% ± 4.68%. After aspirin injection, SAT decreased in 14 patients (77.8%) and was 22.9% after 1 h