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为了研究复合螺旋藻多糖的耐缺氧作用,试验将螺旋藻多糖(PSP)与银杏叶提取物(GBE)按照不同比例复合,以50 mg/(kg·d)剂量分别灌胃小鼠,给药14 d后构建小鼠常压密闭缺氧模型,观察小鼠缺氧存活时间,检测心脏、肝脏、脑组织中丙二醛(MDA)含量,肝脏、脾脏超氧化物歧化酶(SOD)活性等生化指标。结果表明:供试药物均可延长小鼠在常压密闭缺氧条件下的存活时间,提高缺氧小鼠肝脏、脾脏SOD活性,降低缺氧小鼠心脏、肝脏、脑组织中MDA含量。说明供试药物均具有一定的抗疲劳作用,并且PSP与GBE按照2∶1比例复合使用对提高小鼠的抗疲劳能力具有较好的协同增效作用。
In order to study the hypoxia-tolerant effect of polysaccharides from Spirulina platensis, mice were treated with PSP and Ginkgo biloba extract (GBE) in different proportions, and the mice were inoculated with 50 mg / (kg · d) Hypoxia was induced by hypoxia in mice for 14 d after hypoxia. The content of malondialdehyde (MDA), the activity of superoxide dismutase (SOD) in liver and spleen were detected in heart, liver and brain. Other biochemical indicators. The results showed that the tested drugs could prolong the survival time of mice under hypoxic conditions under normal pressure and improve the activity of SOD in liver and spleen of hypoxic mice and decrease the content of MDA in heart, liver and brain of hypoxic mice. Indicating that the test drugs have a certain anti-fatigue effect, and PSP and GBE 2: 1 ratio in combination to improve the anti-fatigue ability of mice has a good synergy.