目的　探讨脆弱类杆菌代谢产物琥珀酸 (succinicacid)对中性粒细胞 (polymorphonuclear,PMN)功能的影响及其在脆弱类杆菌 (bacteroidesfragilis)发病中的作用。方法　体外分离外周血PMN ,以 5 ,10 ,2 0 ,30mmol/L四种浓度的琥珀酸分别孵育 2 0min ,或以 2 0mmol/L浓度的琥珀酸孵育 5 ,10 ,15和 2 0min ,测定对PMN粘附率 (adherencerate)及硝基蓝四氮唑 (NBT)还原能力的影响。结果　琥珀酸能显著抑制PMN粘附率及NBT还原能力 ,且呈浓度 ,时间依赖关系。结论　琥珀酸能抑制PMN的功能 ,在脆弱类杆菌的发病中占有重要的作用。 Objective To investigate the effect of the succinic acid metabolites of Bacteroides fragilis on the function of polymorphonuclear (PMN) and its role in the pathogenesis of Bacteroides fragilis. Methods PMN was isolated from peripheral blood in vitro and incubated with succinic acid at concentrations of 5, 10, 20, 30 mmol / L for 20 min or with 20 mmol / L succinic acid at 5, 10, 15 and 20 min, respectively On PMN adherence rate and NBT reduction ability. Results succinic acid can significantly inhibit the adhesion rate of PMN and NBT reduction ability, and in a concentration-dependent manner. Conclusion Succinic acid can inhibit the function of PMN and play an important role in the pathogenesis of Bacteroides fragilis.