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以N,N’-双(甲基丙烯酰)胱氨酸二甲酯为交联剂,采用蒸馏沉淀聚合法制备了还原敏感聚甲基丙烯酸(PMAA)纳米水凝胶。使用红外光谱仪、激光粒度仪、扫描电子显微镜对纳米水凝胶的组成、粒径及形貌进行了表征,考察了交联剂用量、单体用量、引发剂用量以及反应时间对纳米水凝胶粒径及产率的影响,结果表明,通过改变制备条件可以得到不同尺寸的纳米水凝胶,其中交联剂用量及反应时间对微球粒径的影响最显著,并通过正交实验优化出最佳工艺条件,即n(引发剂)∶n(单体)∶n(交联剂)=1.1∶96∶2.9,反应时间为15 min。此外,该纳米水凝胶在10 mmol/L二硫苏糖醇(DTT)还原性条件下能够在20 min内快速响应降解,展示出良好的还原敏感性能。
Reductively sensitive polymethylmethacrylate (PMAA) nano hydrogels were prepared by distillation precipitation polymerization using N, N’-bis (methacryloyl) cystine as cross-linking agent. The composition, particle size and morphology of nano-hydrogel were characterized by IR, laser particle size analyzer and scanning electron microscope. The effects of crosslinking agent dosage, monomer amount, initiator dosage and reaction time on the stability of nano-hydrogel Particle size and yield. The results show that different sizes of nano-hydrogel can be obtained by changing the preparation conditions. The amount of cross-linking agent and the reaction time have the most significant effect on the particle size of the microspheres. Orthogonal experiments The optimum conditions, namely n (initiator): n (monomer): n (crosslinking agent) = 1.1: 96: 2.9, the reaction time was 15 min. In addition, the nano-hydrogel can rapidly respond to degradation within 20 min under 10 mmol / L dithiothreitol (DTT) reducing conditions, demonstrating good reduction sensitivity.