论文部分内容阅读
目的探究二甲双胍对糖尿病前期干预的疗效及安全性。方法 58例糖尿病前期患者,随机分为治疗组和对照组,各29例。两组均进行生活方式干预,治疗组在此基础上加服二甲双胍片,比较两组治疗效果和糖尿病发病率,观察治疗组的不良反应。结果两组治疗后空腹血糖(FPG)及餐后2小时血糖(2 h PG)均有所下降,治疗组下降更明显,差异均具有统计学意义(P<0.05);治疗组糖尿病发病率明显低于对照组(P<0.01);治疗组共8例患者出现胃肠道反应。结论二甲双胍可以有效降低糖尿病前期的血糖水平,同时可以显著降低糖尿病的发病率,不良反应发生率较低。
Objective To investigate the efficacy and safety of metformin on pre-diabetes mellitus. Methods 58 cases of pre-diabetic patients were randomly divided into treatment group and control group, 29 cases in each. Two groups were carried out lifestyle intervention, the treatment group on the basis of adding metformin tablets, the treatment effect and the incidence of diabetes were compared, the treatment group was observed adverse reactions. Results Both fasting blood glucose (FPG) and 2-hour postprandial blood glucose (2 h PG) decreased after treatment in both groups, and the difference was statistically significant (P <0.05). The incidence of diabetes was significantly higher in the treatment group Lower than the control group (P <0.01); a total of 8 patients in the treatment group had gastrointestinal reactions. Conclusion Metformin can effectively reduce the pre-diabetes blood glucose levels, and can significantly reduce the incidence of diabetes, the incidence of adverse reactions is low.