报道广东首例肾移植术后甄氏外瓶霉致皮肤及皮下组织暗色丝孢霉病临床、实验研究和治疗结果。患者男,66岁,右中指、腕部、前臂皮肤结节、脓疱5月余,无痒痛。脓液涂片显微镜下见分隔、分支,淡棕色菌丝;组织病理见炎性肉芽肿囊性变,其内散在真菌菌丝,PAS、六胺银染色亦见真菌菌丝;沙堡培养基26℃培养菌落呈榄黑色绒毛样,玻片小培养符合甄氏外瓶霉;对所分离菌株进行ITS序列分析,与甄氏外瓶霉同源性为100%;采用Etest法检测了6种抗真菌药物的MIC值,其中二性霉素B、伏立康唑、伊曲康唑、氟康唑敏感,5-氟胞嘧啶、卡泊芬净耐药。局部注射二性霉素B与口服伏立康唑联合抗真菌治疗,及时切除好转较慢及新发皮疹,治疗效果满意。本病例为广东省内首次报道甄氏外瓶霉所致暗色丝孢霉病,亦为肾移植术后所致该病的国内首次报道。 Reported the first case of kidney transplantation in Guangdong Zhen’s Ephedra induced skin and subcutaneous tissue dark silk mold disease clinical, experimental research and treatment results. Patients male, 66 years old, right middle finger, wrist, forearm skin nodules, pustules more than 5 months, no itching pain. Pus smear microscope to see the separation, branching, light brown hyphae; histopathology see inflammatory granuloma cystic degeneration, which scattered in the fungal mycelium, PAS, hexamine silver staining also see fungal hyphae; Sandcastle culture medium The colonies were cultured at 26 ℃ with dark black fleece and small slide culture accorded with Vibrio euphylla. The ITS sequence analysis of the isolated isolates showed 100% homology with Vibrio euphylla; Etest was used to detect 6 species Anti-fungal MIC values, including amphotericin B, voriconazole, itraconazole, fluconazole sensitive, 5-fluorocytosine, caspofungin resistance. Local injection of amphotericin B and oral voriconazole combined antifungal therapy, timely removal and improvement of the slower and new rash, the treatment effect is satisfactory. This case was first reported in Guangdong Province Chen Xia outside bottle mold caused by dark silk mold disease, but also for the first time after kidney transplantation caused the disease in China.