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目的:探讨应用宫颈癌筛查系统初善仪誖(TruScreen誖)与HPV分型检测对宫颈病变的诊断价值。方法:对80例LCT≥ASC的患者依次进行TruScreen检查、HPV分型检测和阴道镜下宫颈活检,将病理结果与TruScreen和HPV结果对照分析。结果:TruScreen和HPV阳性分别为52例和41例,病理学检查阳性为38例。TruScreen、HPV检测CIN的敏感度分别为94.73%、81.58%,特异度分别为61.90%、76.19%,差异有显著性(P<0.05),两种检查的符合率:71.25%。联合检查对高度CIN诊断的敏感度为100%。HPV16、58感染较多出现在高度CIN中。结论:TruScreen可即时检测宫颈病变,敏感度高,联合HPV分型检测对宫颈癌及癌前病变的筛选及预后判断有重要意义。
Objective: To investigate the diagnostic value of cervical precancerous lesions (HPV) detected by the TruScreen Paradox and cervical cancer screening system. Methods: Eighty patients with LCT≥ASC were followed by TruScreen examination, HPV typing test and colposcopic cervical biopsy. The pathological results were compared with the results of TruScreen and HPV. Results: The positives of TruScreen and HPV were 52 and 41, respectively. The positive results of pathology were 38. The sensitivity of TruScreen and HPV in detecting CIN was 94.73% and 81.58% respectively, and the specificity was 61.90% and 76.19%, respectively (P <0.05). The coincidence rate of the two tests was 71.25%. Joint examination of the sensitivity of high CIN diagnosis was 100%. HPV16,58 infection occurs more in high CIN. Conclusion: TruScreen can detect cervical lesions immediately and has high sensitivity. Combined with HPV typing detection, it is important for the screening and prognosis of cervical cancer and precancerous lesions.