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目的探讨急性白血病(AL)诱导化疗反应与疗效及预后的关系。方法采用回顾性分析方法。结果持续缓解2.5年以上的绝大多数AL患者获得早期完全缓解(CR)且缓解时间短。诱导化疗后WBC最低值和骨髓(BM)原始细胞(Blasts)下降程度与1个疗程是否获得CR有明显相关性。化疗后WBC最低值小于1×109/L的患者的体温降至正常后4d左右Plt明显上升或正常,并于化疗后第14天￣第16天BM显示缓解。结论获得早期CR是持续缓解的极为重要的条件。诱导化疗后WBC最低值和骨髓Blasts的下降程度与诱导化疗疗效相关。骨髓抑制后观察外周血Plt的恢复情况可以预见骨髓象情况。
Objective To investigate the relationship between acute leukemia (AL) -induced chemotherapy response and efficacy and prognosis. Methods The method of retrospective analysis. Results The vast majority of AL patients with sustained remission for 2.5 years had early complete response (CR) and had a short response time. The lowest value of WBC and the decrease of bone marrow (Blasts) after induction chemotherapy were significantly correlated with CR of one course of treatment. After chemotherapy, the patients with WBC lowest 1 × 109 / L had normal or abnormal Plt levels after 4 days, and BM was relieved on the 14th to the 16th day after chemotherapy. Conclusion Obtaining early CR is an extremely important condition for sustained remission. The lowest value of WBC and the decrease of bone marrow Blasts after induction chemotherapy are related to the curative effect of induction chemotherapy. Myelosuppression observation of peripheral blood Plt recovery can predict bone marrow like situation.