目的:探讨妊娠期肝内胆汁淤积症(ICP)胆汁酸水平对围产儿结局的影响。方法:以44例ICP患者为观察组,选择同期分娩的48例正常孕妇为对照组,对比两组谷丙转氨酶、胆汁酸、谷草转氨酶水平及妊娠结局。结果:观察组谷丙转氨酶、谷草转氨酶、胆汁酸水平分别为(146.04±36.80)U/L、(94.39±32.44)U/L、(65.41±11.65)μmol/L,明显高于对照组的(37.26±3.14)U/L、(26.72±4.58)U/L、(3.25±0.93)μmol/L,差异有统计学意义(P<0.05)。两组胎儿宫内窘迫、新生儿窒息、新生儿体重及羊水粪染发生率比较,差异有统计学意义(P<0.05)。结论:ICP孕妇的胆汁酸升高可能导致新生儿不良预后,适时终止妊娠有利于改善新生儿结局。 Objective: To investigate the effect of intrahepatic cholestasis of pregnancy (ICP) on perinatal outcome. Methods: Forty-four patients with ICP were selected as the observation group. Forty-eight normal pregnant women of the same period of delivery were selected as the control group. The levels of alanine aminotransferase, bile acid, aspartate aminotransferase, and pregnancy outcome were compared between the two groups. Results The levels of alanine aminotransferase, aspartate aminotransferase and bile acid in the observation group were (146.04 ± 36.80) U / L, (94.39 ± 32.44) U / L and (65.41 ± 11.65) μmol / L, 37.26 ± 3.14) U / L, (26.72 ± 4.58) U / L and (3.25 ± 0.93) μmol / L, respectively. There was significant difference between the two groups (P <0.05). Fetal distress, neonatal asphyxia, neonatal weight and incidence of amniotic fluid meningitis in two groups were significantly different (P <0.05). Conclusion: Increased bile acid in pregnant women with ICP may lead to poor prognosis of newborns. Terminating pregnancy timely may improve neonatal outcome.