本文定时观察了用秋水仙碱处理体外培养恶性疟原虫后的红细胞感染率及环状体、大滋养体和裂殖体各期的比例,并与用山梨醇处理进行了比较。结果发现,秋水仙碱处理后疟原虫可维持2～3个生物周期的同步化发育,并且处理后的红细胞感染率可在14％以上。山梨醇处理后疟原虫可维持2个生物周期的同步化发育,最高红细胞感染率为7.7％。 This paper regularly observed colchicine treatment of P. falciparum in vitro infection rate of erythrocytes and the proportion of ring, large trophozoites and schizonts, and with sorbitol treatment were compared. The results showed that colchicine treatment could maintain the synchronized development of 2-3 biological cycles after colchicine treatment, and the treated erythrocyte infection rate could be over 14%. After the sorbitol treatment, the malaria parasite maintained the synchronized development of two biological cycles with the highest infection rate of erythrocytes being 7.7%.