实验选择6例健康男性青年受试者,采用单盲、随机交叉实验。通过α_1-肾上腺素能受体激动剂去氧肾上腺素的升压反应来评价单次静注0.5 μg/kg abanoquil和安慰剂后1,6,12,25h对心率、血压的影响,并研究了abanoquil在正常人体的作用时间、药动学和浓度效应关系。实验结果:sbanoquil在用药后1h显示最大的α_1-肾上腺素能受体阻滞作用,此后在6,12,25 h呈逐渐下降趋势,直至12 h尚可 Six healthy male youth subjects were selected as experimental subjects, and were single-blind and randomized crossover experiment. The effects of single dose of 0.5 μg / kg abanoquil and placebo on heart rate and blood pressure at 1, 6, 12 and 25 h after single intravenous injection were evaluated by the potentiation of the α 1 -adrenoceptor agonist phenylephrine. The effect of abanoquil on normal human body time, pharmacokinetics and concentration effects. Experimental results: sbanoquil showed the largest α 1 -adrenoceptor blocking effect at 1 h after administration, and then decreased gradually at 6 h, 12 h and 25 h until 12 h